Next-Gen Tankless iNO Therapy

Precision Delivery. Uncompromising Safety

Sianox tankless inhaled nitric oxide (iNO)

Delivery system revolutionizes respiratory care —eliminating gas cylinders while delivering accurate, continuous therapy for neonates and adults.

Transforming Respiratory Care

Reduce ECMO dependency in persistent pulmonary hypertension (PPHN) with precise, stable iNO delivery
Manage post-operative pulmonary hypertension without tank logistics
Lower storage costs & compliance risks
Improve therapy availability
Simplified staff training

Precision and Safety

Mobility and Usability

Areas of application

For Neonates

For Adults

For Hospitals

For Rehabilitation

Why Our iNO System is Different

True Tankless Technology

Generate iNO **on-demand** from medical-grade air—no gas storage, no supply delays, no waste
Switching to tankless iNO cut your supply costs by 60% and eliminated storage headaches

Smarter Dosing

Real-time monitoring** (0–80 ppm)
Auto-adjusting for patient needs
Integrated NO₂ scrubbing

Designed for Clinicians

Lightweight & portable** (ICU to ambulance)
Intuitive touchscreen interface
Backup battery for transport

Research Results

Tankless inhaled nitric oxide (iNO) therapy system is designed to provide precise and continuous treatment for patients with respiratory conditions

Technical specifications

Parameter	Specification
Source gas	Air
NO dose	From 1 ppm to 100 ppm
NO concentration adjustment step	0.1 ppm
Gas temperature at the device outlet	Room temperature
NO and NO2 monitoring	Continuous
Threshold settings	NOmax, NOmin, NO2max
Purging of measurement sensors	Automatic
Power supply	220 V / 50 Hz
Power consumption	No more than 100 watts
Weight	26 kg
Base diameter / height	0.7 m / 1.4 m
Continuous operation time	At least 24 hours

Kit

The therapeutic administration of inhaled nitric oxide (iNO)

Nitric oxide therapy reveals a field in rapid and dynamic evolution. Inhaled nitric oxide is a proven, life-saving intervention for neonatal pulmonary hypertension, with a growing body of evidence supporting its application in a wider range of critical conditions.

Burov Artem Aleksandrovich

PhD in Medical Sciences, anesthesiologist-resuscitator, neonatologist, head of clinical work of the newborn surgery department at the Federal State Budgetary Institution «National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after V.I. Kulakov» of the Ministry of Health of Russia

«In patients with precapillary pulmonary hypertension in the postoperative period of cardiac surgery interventions, therapy with nitric oxide synthesized from atmospheric air allows to reduce pulmonary vascular resistance by 35% and mean pulmonary artery pressure by 16%»

Bautin Andrei Evgenievich

Head of the Research Laboratory of Anesthesiology and Resuscitation at the Federal State Budgetary Institution «V.A. Almazov National Medical Research Centre» of the Ministry of Health of Russia, Professor of the Department of Anesthesiology and Resuscitation, Physician-Anesthesiologist-Resuscitator of the highest category, Distinguished Healthcare Worker, Doctor of Medical Sciences, Associate Professor

«The range of indications for the use of nitric oxide is not limited to cardiovascular diseases. In numerous studies, this device has shown high efficacy in treating patients with acute respiratory distress syndrome, as well as in respiratory failure due to severe pneumonia, including that caused by SARS-CoV-2»

Kamenschikov Nikolai Olegovich

PhD in Medical Sciences, Head of the Critical Care Medicine Laboratory, Physician-Anesthesiologist-Resuscitator of the highest qualification category. Research Institute of Cardiology – Branch of the Federal State Budgetary Scientific Institution «Tomsk National Research Medical Center of the Russian Academy of Sciences»

«Cardiac surgery is a high-risk area for postoperative complications. The widespread use of nitric oxide in routine cardiac surgical practice may improve surgical outcomes. In this regard, there is a significant demand for technological support of the method, which allows addressing logistical difficulties related to the delivery and storage of nitric oxide, as well as reducing the financial costs of conducting NO therapy. 'Sianox' makes nitric oxide therapy accessible for practical healthcare with predictable positive medical and socio-economic effects»

Pichugin Vladimir Viktorovich

Professor of the Department of Anesthesiology, Resuscitation, and Transfusion Medicine at the Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of Russia, Doctor of Medical Sciences, Associate Professor

«Nitric oxide, used in anesthesia and artificial circulation during heart valve surgeries, has a protective effect on the lungs and heart»

Chuchalin Alexander Grigorievich

Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Head of the Department of Hospital Therapy at the Pediatric Faculty of the Federal State Autonomous Educational Institution of Higher Education "N.I. Pirogov Russian National Research Medical University" of the Ministry of Health of Russia, Chief Freelance Consultant in Therapy and Pulmonology of the Presidential Administration of the Russian Federation

«I have never seen any undesirable effects of nitric oxide on a person who works on the operating table, in intensive care, and so on. What needs to be emphasized here, actually? Sianox has ideal characteristics because it does not emit practically any nitrogen dioxide»